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Endocrinology, Vol 100, 246-249, Copyright © 1977 by Endocrine Society

ARTICLES

The effect of hypothalamic deafferentation on somatostatin-like activity in the rat brain

MJ Brownstein, A Arimura, R Fernandez-Durango, AV Schally, M Palkovits and JS Kizer

Somatostatin-like activity (SLA) was determined by radioimmunoassay in several brain regions of animals which had either undergone complete deafferentation of the medial basal hypothalamus or a sham-operation. Surgical isolation of the medial basal hypothalamus caused this region to lose most of its SLA, but did not affect activity elsewhere. Similarly, partial (frontal) deafferentation of the medial basal hypothalamus resulted in a substantial decrease in SLA there.




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Copyright © 1977 by The Endocrine Society