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Endocrinology, Vol 100, 751-754, Copyright © 1977 by Endocrine Society

ARTICLES

Effect of neurotensin, substance P and morphine sulfate on the secretion of prolactin and growth hormone in the rat

C Rivier, M Brown and W Vale
Institute of Biological Studies, La Jolla, California 92037.

Neurotensin (NT), substance P (SP) and morphine sulfate (MS) elevate plasma prolactin and growth hormone levels in both normal or estrogen- progesterone pretreated male rats. By contrast, steroid priming is required for TRF to exhibit PRL-releasing activity. Naloxone, an opiate receptor blocker, reverses the stimulatory effect of MS only. Diphenhydramine, a histamine antagonist, inhibits the response to NT, SP and MS without affecting the response to TRF. These results suggest the involvement of a histaminic step in the action of NT, SP and MS. TRF, NT and SP do not appear to stimulate PRL and GH through activation of an opiate receptor.


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