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Endocrinology, Vol 100, 782-785, Copyright © 1977 by Endocrine Society

ARTICLES

An intrarenal effect of somatostatin on water excretion

IA Reid and JC Rose
Department of Physiology, University of California, San Francisco 94143.

Intrarenal infusion of somatostatin in anesthetized dogs produced a prompt increase in urine flow in association with a decrease in urinary osmolality and an increase in free water clearance. These changes occurred in the absence of changes in arterial pressure, renal plasma flow, osmolar clearance, electrolyte excretion or cyclic AMP excretion. The diuretic effect occurred primarily in the infused kidney indicating a direct intrarenal action rather than suppression of vasopressin secretion. This diuretic action of somatostatin may result from inhibition of the action of vasopressin on the renal medulla but other possible mechanisms cannot be excluded.


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J. Bolaffi, S Reichlin, D. Goodman, and J. Forrest Jr
Somatostatin: occurrence in urinary bladder epithelium and renal tubules of the toad, Bufo marinus
Science, November 7, 1980; 210(4470): 644 - 646.
[Abstract] [PDF]


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