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Endocrinology, Vol 100, 1723-1726, Copyright © 1977 by Endocrine Society

ARTICLES

Release of gonadotrophin-releasing hormone (Gn-RH) from isolated, perifused medial-basal hypothalamus by melatonin

LW Kao and J Weisz

Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1-10 mM) as 10- 20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10-20 min pulses of melatonin (0.1-1.0 mM) consistently caused release of Gn-RH.


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