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Endocrinology, Vol 101, 312-314, Copyright © 1977 by Endocrine Society

ARTICLES

The site of insulin resistance after injury

KN Frayn

Intracellular glucose concentrations in skeletal muscle have been measured in normal and injured rats individually infused with 51Cr-EDTA as an extracellular space marker. In normal rats, even when infused with glucose at a high rate, membrane transport appeared to be the rate- limiting step in glucose utilization by muscle. After injury the concentration of intracellular glucose was increased, and positively correlated with that in plasma, showing that the loss of sensitivity to insulin after injury is due to impairment of an intracellular metabolic step.


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 Am. J. Physiol. Endocrinol. Metab.Home page
A. Thorell, J. Nygren, M. F. Hirshman, T. Hayashi, K. S. Nair, E. S. Horton, L. J. Goodyear, and O. Ljungqvist
Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization
Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E754 - E761.
[Abstract] [Full Text] [PDF]


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