Endocrinology, Vol 101, 627-630, Copyright © 1977 by Endocrine Society
Estrogen hormones and lipid metabolism. Effect of ethynyl-estradiol on liver lipases
A Valette, A Verine, P Salers and J Boyer
Lipase activities assayed in liver subcellular fractions from rats given
ethynyl-estradiol are lowered, while triglycerides increase and cholesterol
decreases in blood. Triester lipase in microsomes is the most altered
activity. Such enzymatic changes might play a role in the development of
lipid abnormalities in blood of women taking estrogens as oral
contraceptives.