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Somatostatin: A Physiological Role in the Regulation of Growth Hormone Secretion in the Adolescent Male Baboon^*

ROBERT A. STEINER^,, JENNIFER K. STEWART, JACQUEY BARBER, DONNA KOERKER^||, C. J. GOODNER, ARTHUR BROWN, PAVEL ILLNER and C. C. GALE

Departments of Physiology and Biophysics, Medicine and Regional Primate Research Center, University of Washington Seattle, Washington 98195

Abstract

Insulin and GH secretion patterns were surveyed in four adolescent male baboons before and after active immunization against cyclic somatostatin. Before immunization, an ultradian GH rhythm with an interpeak interval of 4.1 ± 0.33 (SE) h was observed during a 12-h daylight sampling period. The rhythm was characterized by 2- to 12-fold increases in serum GH concentration; each burst was maintained over 3.15 ± 0.25 h. After immunization, baseline serum GH concentration was increased and episodic bursts of GH secretion were markedly diminished. The total integrated areas over 12 h did not differ between the control and postimmunization studies. A comparison of the autocorrelation analyses of GH secretion before and after active immunization revealed that the immunization procedure effected a disruption of the synchronous ultradian GH rhythm observed before treatment.

Basal plasma insulin and glucose concentrations were observed in overnight-fasted subjects. There was no apparent effect of the immunization procedure on the mean plasma concentrations of either insulin or glucose. Furthermore, the immunization procedure did not alter patterns of the plasma insulin and glucose concentrations observed during iv arginine infusion or glucose tolerance testing.

We conclude from these studies that blood-borne somatostatin contributes significantly to the physiological regulation of GH secretion in the adolescent male baboon; however, we were unable to obtain evidence to support the hypothesis that circulating somatostatin is important in the dynamics of insulin/glucose regulation in this primate species. (Endocrinology 102: 000, 1978)

Footnotes

^* This work was supported in part by NIH grants RR0016, NS 06622, AM 17047, and AM 10866.

Postdoctoral Fellow of the NIH.

To whom requests for reprints should be addressed.

Undergraduate Scholar at Hampshire College in Amherst, MA.

^|| Howard Hughes Medical Institute Investigator.

Received April 5, 1977.

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