Endocrinology, Vol 102, 1645-1648, Copyright © 1978 by Endocrine Society

ARTICLES

Persistent estrus and blockade of progesterone-induced LH release follows lesions which do not damage the suprachiasmatic nucleus

SJ Wiegand, E Terasawa and WE Bridson

Very small electrolytic lesions were made over the anterior or posterior portion of the optic chiasm in mature female rats showing normal estrous cycles. Lesions over the posterior portion of chiasm destroyed the suprachiasmatic nucleus of the hypothalamus (SCN) while the anterior lesions destroyed a small neural structure, here designated as the medial preoptic nucleus (MPN). Both lesions were effective in inducing persistent vaginal estrus, but when animals were ovariectomized and treated with exogenous and progesterone it was found that lesions including the MPN alone, but not the SCN alone, eliminated the positive feedback effects of this steroid regimen on LH release.

This article has been cited by other articles:

				H. M. Dungan, M. L. Gottsch, H. Zeng, A. Gragerov, J. E. Bergmann, D. K. Vassilatis, D. K. Clifton, and R. A. Steiner The Role of Kisspeptin GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone J. Neurosci., October 31, 2007; 27(44): 12088 - 12095. [Abstract] [Full Text] [PDF]

				A. S. Kauffman, M. L. Gottsch, J. Roa, A. C. Byquist, A. Crown, D. K. Clifton, G. E. Hoffman, R. A. Steiner, and M. Tena-Sempere Sexual Differentiation of Kiss1 Gene Expression in the Brain of the Rat Endocrinology, April 1, 2007; 148(4): 1774 - 1783. [Abstract] [Full Text] [PDF]

				J. H. Morrison, R. D. Brinton, P. J. Schmidt, and A. C. Gore Estrogen, Menopause, and the Aging Brain: How Basic Neuroscience Can Inform Hormone Therapy in Women J. Neurosci., October 11, 2006; 26(41): 10332 - 10348. [Full Text] [PDF]

				A. Fukushima, P. Yin, M. Ishida, N. Sugiyama, and J. Arita Pup removal suppresses estrogen-induced surges of LH secretion and activation of GnRH neurons in lactating rats. J. Endocrinol., October 1, 2006; 191(1): 339 - 348. [Abstract] [Full Text] [PDF]

				J. T. Smith, S. M. Popa, D. K. Clifton, G. E. Hoffman, and R. A. Steiner Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J. Neurosci., June 21, 2006; 26(25): 6687 - 6694. [Abstract] [Full Text] [PDF]

				J. S. Perrin, L. A. Segall, V. L. Harbour, B. Woodside, and S. Amir The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle PNAS, April 4, 2006; 103(14): 5591 - 5596. [Abstract] [Full Text] [PDF]

				I. Merchenthaler, G. E. Hoffman, and M. V. Lane Estrogen and Estrogen Receptor-{beta} (ER{beta})-Selective Ligands Induce Galanin Expression within Gonadotropin Hormone-Releasing Hormone-Immunoreactive Neurons in the Female Rat Brain Endocrinology, June 1, 2005; 146(6): 2760 - 2765. [Abstract] [Full Text] [PDF]

				C. Orikasa, Y. Kondo, S. Hayashi, B. S. McEwen, and Y. Sakuma Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge PNAS, February 14, 2002; (2002) 52707299. [Abstract] [Full Text] [PDF]

				W.-W. Le, P. M. Wise, A. Z. Murphy, L. M. Coolen, and G. E. Hoffman Parallel Declines in Fos Activation of the Medial Anteroventral Periventricular Nucleus and LHRH Neurons in Middle-Aged Rats Endocrinology, November 1, 2001; 142(11): 4976 - 4982. [Abstract] [Full Text] [PDF]

				W. W. Le, K. A. Berghorn, S. Rassnick, and G. E. Hoffman Periventricular Preoptic Area Neurons Coactivated with Luteinizing Hormone (LH)-Releasing Hormone (LHRH) Neurons at the Time of the LH Surge Are LHRH Afferents Endocrinology, January 1, 1999; 140(1): 510 - 519. [Abstract] [Full Text]

				D. Swaab and E Fliers A sexually dimorphic nucleus in the human brain Science, May 31, 1985; 228(4703): 1112 - 1115. [Abstract] [PDF]

				C. Orikasa, Y. Kondo, S. Hayashi, B. S. McEwen, and Y. Sakuma Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge PNAS, March 5, 2002; 99(5): 3306 - 3311. [Abstract] [Full Text] [PDF]