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Endocrinology, Vol 103, 1-5, Copyright © 1978 by Endocrine Society

ARTICLES

Adrenal steroidogenesis in methylandrostenediol-induced hypertension

AL McCall, J Stern, SL Dale and JC Melby

Adrenal vein catheterizations were done in rats made hypertensive by administration of methylandrostenediol (MAD; 17alpha-methyl-5- androstene-3beta,-17beta-diol), and in control rats at intervals during treatment. All MAD-treated rats were hypertensive by 7 weeks. Secretion of corticosterone was consistently decreased at all times in MAD- treated rats. 18-Hydroxy-11-deoxycorticosterone secretion and 11- deoxycorticosterone (DOC) secretion decreased and increased, respectively, compared to controls at 2, 4, and 6 weeks. Aldosterone secretion was decreased at 2 and 4 weeks. This study shows an in vivo block of adrenal 11- and 18-hydroxylation. Transient DOC accumulation by treatment with MAD produced hypertension, though DOC oversecretion and other changes in steroidogenesis were waning by the time hypertension developed.




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Copyright © 1978 by The Endocrine Society