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Endocrinology, Vol 103, 96-100, Copyright © 1978 by Endocrine Society

ARTICLES

Metabolic clearance of endogenous and radioiodinated thyroglobulin in rats

M Izumi and PR Larsen

The basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (Tg) were measured in normal male rats. Serum Tg concentrations (by RIA) in Sprague-Dawley adult males ranged from 70- 680 ng/ml (mean +/- SD, 218 +/- 177). In male Fisher rats, basal serum Tg concentrations were 32-263 ng/ml. The fractional disappearance rate of endogenously radioiodinated rat Tg and of endogenous rat Tg after thyroidectomy were both about 8%/h. The MCR of endogenously labeled Tg was 2.4 +/- 1.1 ml/100 g/h. Using this clearance and the mean serum Tg concentration in these rats, a daily thyroidal release rate of about 201 microgram Tg/100 g BW would be required to provide the T4 metabolized daily by the rat, the Tg released into the circulation comprises about 7% of the total rat Tg produced in a 24-h period.




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