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Participation of Serotonin in Thyrotropin Release. I. Evidence for the Action of Serotonin on Thyrotropin Releasing Hormone Release^*

Laboratoire de Physiopathologie Endocrinienne Hôpital de l'Antiquaille 69321 Lyon, France

Address requests for reprints to: Dr. D. Jordan, Laboratoire de Physiopathologie Endocrinienne, Hopital de l'Antiquaille, 1 rue de l'Antiquaille, 69321 Lyon Cedex 1, France.

Abstract

Injection of serotonin (5-HT) into the third ventricle of the rat resulted in a rapid increase of serum TSH; a significant effect was observed 5 min after injection, whereas the maximal effect appeared 10 min after the injection of 1 µg 5-HT. This stimulating effect of 5-HT was completely prevented by pretreatment with cyproheptadine, a blocker of 5-HT receptors, whereas fluphenazine, a dopamine receptor blocker, was unable to block it. Third venticle injection of 5-HT in rats bearing anterior hypothalamic lesions (which did not affect the suprachiasmatic nucleus or the medio-basal hypothalamus) also induced an increase of serum TSH similar to that observed in normal rats despite the fact that these animals show a lower basal TSH. In vitro, the addition of 5-HT to an incubation medium containing one hemi-anterior pituitary did not modify medium TSH, whereas 5-HT addition induced an increase of medium TSH in the system containing one hemi-anterior pituitary and two hypothalami. We conclude that 5-HT acts on TSH function probably through a stimulation of TRH release

Footnotes

^* This work was supported by a grant from the Institut National de la Sante et de la Recherche Medicale (74-1–450-35). It was presented in part at the Fifth International Congress of Endocrinology, Hamburg, Germany, July 18–24, 1976.

Received June 4, 1977.