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Endocrinology, Vol 103, 641-643, Copyright © 1978 by Endocrine Society

ARTICLES

Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, Des- Gly-NH210] LHRH ethylamide

G Pelletier, L Cusan, C Auclair, PA Kelly, L Desy and F Labrie

The effect of treatment with a potent LHRH agonist, [D-Ala6, Des-Gly- NH210]LHRH ethylamide, injected at the low dose of 100 ng, twice a week, was evaluated on spermatogenesis in the rat. Significant degenerative changes of seminiferous tubules could be observed after two weeks of treatment. These changes were progressive and led to a marked inhibition of spermatogenesis after four to eight weeks of treatment. Testis weight was decreased to approximately 50% of control after eight weeks of treatment.


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