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Endocrinology, Vol 103, 652-655, Copyright © 1978 by Endocrine Society

ARTICLES

Inhibition by adenosine of thyroidal T4 release in vitro

ML Maayan, EM Volpert and F Dawry

Adenosine, like catecholamines, inhibits the thyroidal T4 release in vitro, when stimulated by TSH,N,O'-dibutyryl cyclic AMP [(Bu) 2cAMP], and phosphodiesterase inhibitors. Unlike catecholamines, the adenosine- induced inhibition is independent of adrenergic receptors. It is postulated that TSH stimulates thyroidal T4 release through a cAMP activated, adenosine-sensitive, protein kinase.




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Copyright © 1978 by The Endocrine Society