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Endocrinology, doi:10.1210/endo-103-5-1579
Endocrinology Vol. 103, No. 5 1579-1582
Copyright © 1978 by the Endocrine Society.
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Glucose and Insulin in the Regulation of Glucagon Release from the Isolated Perfused Dog Stomach*

PIERRE J. LEFEBVRE and ALFRED S. LUYCKX{dagger}

Division of Diabetes, Institute of Medicine, University of Liège B-4020 Liège, Belgium

Address reprint requests to: Dr. P. J. Lefebvre, Institut de Médecine, Hôpital de Bavière, B-4020 Liege, Belgium.

Abstract

The respective roles of glucose and insulin in the regulation of glucagon release from the canine stomach were investigated using an isolated blood-perfused preparation. At normal blood glucose and plasma insulin levels, the stomach released small amounts of glucagon. Such basal gastric glucagon release was not modified by hyperglycemia. In contrast, gastric glucagon release was increased by hypoglycemia or 2-deoxy-D-glucose-induced cytoglycopenia. Antibody neutralization of basal circulating concentrations of insulin (10 ± 1 µU/ml) doubled the stimulation induced by hypoglycemia alone. It is concluded that: 1) suppression of gastric glucagon release is observed with very low concentrations of insulin; 2) basal gastric glucagon release is not further suppressed by hyperglycemia; and 3) that hypoglycemia and cytoglycopenia stimulate gastric glucagon secretion.

Footnotes

* This work was supported by the Fonds National de la Recherche Scientifique and the Fonds de la Recherche Scientifique Medicale of Belgium; presented in part at the American Diabetes Association Meeting June 5-7, 1977, St. Louis, MO.

{dagger} Maitre de Recherches of the F.N.R.S.

Received October 11, 1977.






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Copyright © 1978 by The Endocrine Society