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Comparison of Luteolytic Potencies of Aminoglutethimide Enantiomers in the Rabbit and Rat^*

Department of Population Sciences, Harvard School of Public Health and the Department of Obstetrics and Gynecology, Harvard Medical School the Department of Community Medicine, Dartmouth Medical School Boston, Massachusetts 0211,Hanover, New Hampshire 03755

Address requests for reprints to Dr. Hilton A. Salhanick, Department of Population Sciences, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115.

Abstract

The luteolytic potency of D- and L-aminoglutethimide (D- and L-AG) was compared in in vivo assays in the rat and rabbit. By assay of plasma progesterone depletion in the rabbit, the potency of L-AG relative to D-AG was 0.21. By the plasma procedure in the rat, the relative potencies of L-AG and of the racemic mixture to D-AG were 0.04 and 0.37, respectively. By the ovarian progesterone depletion method, the L-form had very little activity and the DL-mixture was half as active as the D-isomer. Thus, in both species, almost all of the activity of the racemic mixture results from the content of D-AG. Interpretation of paradoxical data implies that in the rat, L-AG may inhibit liver degradation of progesterone at levels which do not modify secretion from the corpus luteum.

Footnotes

^* This work was supported in part by USPHS Grant AM-10081 from the NIAMDD, NIH, and by Research Contract NIH-70-2319 from the NICHHD.

Received November 28, 1977.

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