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Endocrinology, Vol 103, 1605-1610, Copyright © 1978 by Endocrine Society

ARTICLES

Comparison of luteolytic potencies of aminoglutethimide enantiomers in the rabbit and rat

CA Whipple, T Colton, JM Strauss, J Hourihan and HA Salhanick

The luteolytic potency of D- and L-aminoglutethimide (D- and L-AG) was compared in in vivo assays in the rat and rabbit. By assay of plasma progesterone depletion in the rabbit, the potency of L-AG relative to D- AG was 0.21. By the plasma procedure in the rat, the relative potencies of L-AG and of the racemic mixture to D-AG were 0.04 and 0.37, respectively. By the ovarian progesterone depletion method, the L-form had very little activity and the DL-mixture was half as active as the D- isomer. Thus, in both species, almost all of the activity of the racemic mixture results from the content of D-AG. Interpretation of paradoxical data implies that in the rat, L-AG may inhibit liver degradation of progesterone at levels which do not modify secretion from the corpus luteum.


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