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Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen^*

Department of Medicine, The University of Texas Health Science Center at San Antonio SanAntonio, Texas 78284

Address requests for reprints to: Dr. William L. Mc- Guire, Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio,Texas 78284

Abstract

Estrogen antagonists are widely used in the treatment of breast cancer, and studies of their mechanism of action may provide clues to an understanding of tumor growth regulation and mechanisms ofnormal estrogen action. We have used human breastcancer cells in long term culture as an in vitro model tostudy the roles of estradiol and the antiestrogens, tamoxifenand nafoxidine, on cell growth and progesteronereceptor (PgR) induction.

Footnotes

^* This work was supported by the National Cancer Institute (CA-11378 and CB-23862) and The Robert A.Welch Foundation

Received January 27, 1978.

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