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Stimulation of Ovine Placental Lactogen Secretion by Arginine Infusion^*,

S. HANDWERGER, M. C. CRENSHAW, A. LANSING, A. GOLANDER, T.W HURLEY and R.E. FELLOWS^¶

Departments of Pediatrics, Physiology, and Obstetrics and Gynecology, Duke University Medical Center Durham, North Carolina 27710

Address reprint requests to: Dr. Stuart Handwerger,Department of Pediatrics, Duke University Medical Center, Durham, NC 27710

Abstract

Arginine has been demonstrated to be a potent stimulus to GH and PRL secretion. To determine the effect of arginine on plasma ovine placental lactogen (oPL) concentrations, arginine (50 g in 350 ml distilled water, pH 7.4) or hypertonic saline of identical volume, osmolality, and pH was infused iv over a 30-min period into nine pregnant ewes, and blood samples from chronic indwelling venous catheters were obtained at frequent intervals before and for 8 h after the infusions. After the infusion of hypertonic saline, plasma oPL concentrations (measured by homologous RIA) decreased 20–50% over 1–2 h and then returned to baseline concentrations. After the infusion of arginine, plasma oPL concentrations also decreased by 20–50% for 1–2 h. However, 2–3 h after the infusion, plasma oPL concentrations in

Footnotes

^* This research was supported by grants from the NIH (HD-07447) and the National Foundation-March of Dimes (1-297).

Presented in part at the 59th Annual Meeting of the Endocrine Society, Chicago, Illinois, June 1977 (Endocrinology 100: A116, 1977).

USPHS Research Career Development Awardee (HD00065).

Recipient of a Special Research Fellowship (HD05508) from the USPHS.

^¶ Present address: Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242.

Received January 27, 1978.