help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cutler, G. B.
Right arrow Articles by Loriaux, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cutler, G. B., Jr
Right arrow Articles by Loriaux, D. L.

Endocrinology, Vol 103, 2112-2118, Copyright © 1978 by Endocrine Society

ARTICLES

Adrenarche: a survey of rodents, domestic animals, and primates

GB Cutler Jr, M Glenn, M Bush, GD Hodgen, CE Graham and DL Loriaux

The concentrations of the adrenal steroids dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), and delta 4- androstenedione (delta 4-A) have been measured by RIA before and after sexual maturation in plasma of rodents, domestic animals, and primates to determine whether these species exhibit and adrenarchal process comparable to man. The average concentrations of DHA and DHAS were less than 60 ng/dl and 5 microgram/dl, respectively, in plasma of sexually mature rodents and domestic animals, and a significant increase in the plasma DHA level after sexual maturation was seen only in the rabbit and dog. The concentrations of DHA, DHAS, and delta 4-A in 21 rhesus monekeys from 0-3 yr of age were 2021 +/- 235 ng/dl (mean +/- SE), 357 +/- 60 microgram/dl, and 107 +/- 9 ng/dl, respectively, and did not increase during sexual maturation. By contrast, DHA, DHAS, and delta 4- A levels in plasma of chimpanzees were 5.9-fold, 3.3-fold, and 4.8-fold greater, respectively, in 7- to 22-compared to 0- to 3-yr-old animals. Temporally, the increase in DHA levels in the chimpanzee is apparent at 5 yr and this precedes the increase in gonadal steroids, as is characteristic of human adrenarche. It is apparent that adrenal androgen levels and their developmental patterns differ markedly among species, and that among the species examined, only the chimpanzee exhibits an adrenarche comparable to that of man.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
D. H Abbott, D. K Barnett, J. E Levine, V. Padmanabhan, D. A Dumesic, S. Jacoris, and A. F Tarantal
Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys
Biol Reprod, July 1, 2008; 79(1): 154 - 163.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
E. Samandari, P. Kempna, J.-M. Nuoffer, G. Hofer, P. E Mullis, and C. E Fluck
Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3{beta}-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities
J. Endocrinol., December 1, 2007; 195(3): 459 - 472.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
D. Pignatelli, F. Xiao, A. M Gouveia, J. G Ferreira, and G. P Vinson
Adrenarche in the rat.
J. Endocrinol., October 1, 2006; 191(1): 301 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Simard, M.-L. Ricketts, S. Gingras, P. Soucy, F. A. Feltus, and M. H. Melner
Molecular Biology of the 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Gene Family
Endocr. Rev., June 1, 2005; 26(4): 525 - 582.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
E. Corsini, M. Racchi, E. Sinforiani, L. Lucchi, B. Viviani, G. E. Rovati, S. Govoni, C. L. Galli, and M. Marinovich
Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone
J. Leukoc. Biol., February 1, 2005; 77(2): 247 - 256.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
P. J. Hornsby
Aging of the Human Adrenal Cortex
Sci. Aging Knowl. Environ., September 1, 2004; 2004(35): re6 - re6.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. G. Beck and R. J. Handa
Dehydroepiandrosterone (DHEA): A Misunderstood Adrenal Hormone and Spine-Tingling Neurosteroid?
Endocrinology, March 1, 2004; 145(3): 1039 - 1041.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. B. Nunez, K. Calis, G. B. Cutler Jr., J. Jones, and P. P. Feuillan
Lack of Efficacy of Fadrozole in Treating Precocious Puberty in Girls with the McCune-Albright Syndrome
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5730 - 5733.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. V. Pandey, S. H. Mellon, and W. L. Miller
Protein Phosphatase 2A and Phosphoprotein SET Regulate Androgen Production by P450c17
J. Biol. Chem., January 24, 2003; 278(5): 2837 - 2844.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. Arlt, J. W. M. Martens, M. Song, J. T. Wang, R. J. Auchus, and W. L. Miller
Molecular Evolution of Adrenarche: Structural and Functional Analysis of P450c17 from Four Primate Species
Endocrinology, December 1, 2002; 143(12): 4665 - 4672.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. Arlt, F. Callies, I. Koehler, J. C. van Vlijmen, M. Fassnacht, C. J. Strasburger, M. J. Seibel, D. Huebler, M. Ernst, M. Oettel, et al.
Dehydroepiandrosterone Supplementation in Healthy Men with an Age-Related Decline of Dehydroepiandrosterone Secretion
J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4686 - 4692.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. O. Klein, K. M. Barnes, J. V. Jones, P. P. Feuillan, and G. B. Cutler Jr.
Increased Final Height in Precocious Puberty after Long-Term Treatment with LHRH Agonists: The National Institutes of Health Experience
J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4711 - 4716.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Callies, M. Fassnacht, J. C. van Vlijmen, I. Koehler, D. Huebler, M. J. Seibel, W. Arlt, and B. Allolio
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency: Effects on Body Composition, Serum Leptin, Bone Turnover, and Exercise Capacity
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 1968 - 1972.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
L. Ibáñez, J. DiMartino-Nardi, N. Potau, and P. Saenger
Premature Adrenarche--Normal Variant or Forerunner of Adult Disease?
Endocr. Rev., December 1, 2000; 21(6): 671 - 696.
[Abstract] [Full Text]

Home page
 Exp. Biol. Med.Home page
D. R. Pieper and C. A. Lobocki
Characterization of Serum Dehydroepiandrosterone Secretion in Golden Hamsters
Experimental Biology and Medicine, September 1, 2000; 224(4): 278 - 284.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
J. A Yanovski, A. L Diament, K. N Sovik, T. T Nguyen, H. Li, N. G Sebring, and C. H Warden
Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children
Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1405 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Bross, M. Javanbakht, and S. Bhasin
Anabolic Interventions for Aging-Associated Sarcopenia
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3420 - 3430.
[Full Text] [PDF]

Home page
 NEJMHome page
W. Arlt, F. Callies, J. C. van Vlijmen, I. Koehler, M. Reincke, M. Bidlingmaier, D. Huebler, M. Oettel, M. Ernst, H. M. Schulte, et al.
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
N. Engl. J. Med., September 30, 1999; 341(14): 1013 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. J. Auchus and W. L. Miller
Molecular Modeling of Human P450c17 (17{alpha}-Hydroxylase/ 17,20-Lyase): Insights into Reaction Mechanisms and Effects of Mutations
Mol. Endocrinol., July 1, 1999; 13(7): 1169 - 1182.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. S. Gell, B. R. Carr, H. Sasano, B. Atkins, L. Margraf, J. I. Mason, and W. E. Rainey
Adrenarche Results from Development of a 3{beta}-Hydroxysteroid Dehydrogenase-Deficient Adrenal Reticularis
J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3695 - 3701.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Flück, J. Deladoey, K. Rutishauser, A. Eblé, U. Marti, W. Wu, and P. E. Mullis
Phenotypic Variability in Familial Combined Pituitary Hormone Deficiency Caused by a PROP1 Gene Mutation Resulting in the Substitution of Arg->Cys at Codon 120 (R120C)
J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3727 - 3734.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. J. Auchus, T. C. Lee, and W. L. Miller
Cytochrome b5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer
J. Biol. Chem., February 6, 1998; 273(6): 3158 - 3165.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
O. T. Wolf, O. Neumann, D. H. HELLHAMMER, A. C. Geiben, C. J. Strasburger, R. A. Dressendorfer, K.-M. Pirke, and C. Kirschbaum
Effects of a Two-Week Physiological Dehydroepiandrosterone Substitution on Cognitive Performance and Well-Being in Healthy Elderly Women and Men
J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2363 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. Mesiano and R. B. Jaffe
Developmental and Functional Biology of the Primate Fetal Adrenal Cortex
Endocr. Rev., June 1, 1997; 18(3): 378 - 403.
[Abstract] [Full Text]

Home page
 ScienceHome page
F. King, C. Yarbrough, D. Anderson, T. Gordon, and K. Gould
Primates
Science, June 10, 1988; 240(4858): 1475 - 1482.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1978 by The Endocrine Society