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Endocrinology, Vol 104, 1000-1002, Copyright © 1979 by Endocrine Society

ARTICLES

Effects of ouabain on insulin release, adenosine 3',5'-monophosphate and guanine 3',5'-monophosphate in pancreatic islets

E Gagerman, B Hellman and IB Taljedal

Isolated pancreatic islets of noninbred ob/ob mice were used to test the hypothesis that adenylate cyclase responds to changes of the transmembrane milieu or electric field in intact beta-cells. In the presence of a phosphodiesterase inhibitor, ouabainstimulated both the release of insulin and the islet content of cAMP. Ouabain had no noticeable effect on the islet content of cGMP. These results support the hypothesis at test. However, because ouabain also had some stimulatory effect on cAMP in islet homogenates, a direct action of ouabain on adenylate cyclase cannot be ruled out.


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Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes
Am J Physiol Cell Physiol, July 1, 2008; 295(1): C100 - C110.
[Abstract] [Full Text] [PDF]


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