Endocrinology, Vol 104, 857-861, Copyright © 1979 by Endocrine Society

ARTICLES

Circannual variation and genetic regulation of hepatic testosterone hydroxylase activities in inbred strains of mice

HC Ford, E Lee and LL Engel

Hydroxylation of testosterone by hepatic microsomes at positions 6 alpha, 6 beta, 7 alpha, 15 alpha, and 16 alpha has been studied in C57BL/6J, 129/J, and A/J mice. Differences in hydroxylase activities between the C57BL/6J and A/J strains and between the C57BL/6J and 129/J strains were investigated using standard genetic breeding protocols. In the C57BL/6J X A/J line, 6 alpha- and 7 alpha-hydroxylase activity appeared to be under polygenic control in both sexes, as did 15 alpha- hydroxylase activity in females. The lack of 16 alpha-hydroxylase activity observed in 129/J females behaved as a recessive, autosomal, single locus, sex-limited trait. In several instances, the level of hydroxylase activity at one position appeared to be affected by the level of hydroxylase activity at a second position; however, no clear- cut pattern was discerned. Over a period of a year, a remarkable cycle in total hydroxylase activity for all mice was observed; the average activity was greatest in December and least in April.

This article has been cited by other articles:

				S.-H. Park, X. Liu, L. Hennighausen, H. W. Davey, and D. J. Waxman Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression. IMPACT OF Stat5a GENE DISRUPTION J. Biol. Chem., March 12, 1999; 274(11): 7421 - 7430. [Abstract] [Full Text] [PDF]