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Endocrinology, Vol 104, 1553-1558, Copyright © 1979 by Endocrine Society

ARTICLES

Metabolism of sex steroids in the human and canine vas deferens

GM Dupuy, P Boulanger, KD Roberts, G Bleau and A Chapdelaine

The contribution of the vas deferens to the metabolism of steroids was investigated in the human and in the dog by perfusion experiments and in vitro incubation. Perfusion of testosterone or androstenedione through the canine vas deferens resulted in the formation of dihydrotestosterone; no significant formation of estrogens could be detected. When dihydrotestosterone was perfused, 3alpha- and 3beta- androstanediols were isolated. In vitro incubation experiments with human was deferencs have shown an active metabolism of androgens by this time and, therefore, confer a new role to the vas deferens in the male.




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Copyright © 1979 by The Endocrine Society