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Endocrinology, Vol 104, 1794-1796, Copyright © 1979 by Endocrine Society

ARTICLES

In vivo 24-hydroxylation of 25-hydroxyvitamin D3 in enterocolectomized rats

R Kumar, P Silva and FH Epstein

To determine if the renal 25-hydroxyvitamin D3 24-hydroxylase is active in addition to the intestinal 25-hydroxyvitamin D3 24-hydroxylase in vivo in the rat, radiolabeled 25-hydroxyvitamin D3 was administrated to normocalcemic, vitamin D-replete, enterocolectomized rats. Substantial amounts of 24,25-dihydroxyvitamin D3 were detected and the identity of the isolated plasma 24,25-hydroxyvitamin D3 region in these animals were confirmed by coelution on high pressure liquid chromatography and periodate cleavage. This suggests that both intestinal and renal 25- hydroxyvitamin D3 24-hydroxylases are active in vivo in the rat.




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Copyright © 1979 by The Endocrine Society