This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HOFFMANN, J. C. Articles by SCHWARTZ, N. B. Search for Related Content PubMed PubMed Citation Articles by HOFFMANN, J. C. Articles by SCHWARTZ, N. B.

Selective Suppression of the Primary Surge of Follicle- Stimulating Hormone in the Rat: Further Evidence for Folliculostatin in Porcine Follicular Fluid^*

Departments of Anatomy and Reproductive Biology, University of Hawaii School of Medicine, Honolulu, Hawaii 96822; and the Department of Biological Sciences, Northwestern University Evanston, Illinois 60201

Address all correspondence and requests for reprints to: Dr. Neena B. Schwartz, Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201.

Abstract

Charcoal-extracted porcine follicular fluid (PFF), when injected at 1200 h on proestrus, blocked the primary FSH surge seen at 1700 and at 1830 h without affecting the LH surge. In contrast, if the injection was withheld until 1330 h, the FSH surge occurred in the normal way at 1700 h but was suppressed at the 1830 h autopsy. The suppression of FSH by 0.5 ml PFF at 1200 h had abated by 0400 h of estrus. The blockade of the primary surge of FSH at 1700 and 1830 h did not prevent ovulation, nor did it prevent the expected rise in serum progesterone or fall of estradiol levels. There appears to be a latency of at least 3.5 h, when PFF is administered ip, before FSH can be suppressed. This latency occurs whether the injection is carried out in intact proestrous rats or in acutely or chronically ovariectomized females.

Footnotes

^* A preliminary report of this work has been published [Fed Proc 37: 724, 1978 (Abstract)]. This work was supported by USPHS Grant HD-07405 (to N.B.S.).

Received August 18, 1978.

This article has been cited by other articles:

				P. Lamba, M. M Santos, D. P Philips, and D. J Bernard Acute regulation of murine follicle-stimulating hormone {beta} subunit transcription by activin A J. Mol. Endocrinol., February 1, 2006; 36(1): 201 - 220. [Abstract] [Full Text] [PDF]

				T. Woodruff, J D'Agostino, N. Schwartz, and K. Mayo Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle Science, March 11, 1988; 239(4845): 1296 - 1299. [Abstract] [PDF]