help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Endocrinology, doi:10.1210/endo-105-1-52
Endocrinology Vol. 105, No. 1 52-57
Copyright © 1979 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GRAVES, P. E.
Right arrow Articles by SALHANICK, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GRAVES, P. E.
Right arrow Articles by SALHANICK, H. A.

Stereoselective Inhibition of Aromatase by Enantiomers of Aminoglutethimide*

P. E. GRAVES{dagger} and H. A. SALHANICK

Department of Population Sciences, Harvard School of Public Health, and the Department of Obstetrics and Gynecology Harvard Medical School Boston, Massachusetts 02115

Address requests for reprints to: H. A. Salhanick, Ph.D., M.D., Department of Population Sciences, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115.

Abstract

The dextrorotatory enantiomer of aminoglutethimide is 38 times more potent than the levoenantiomer in inhibiting aromatization of testosterone by human placental microsomes. The spectral affinity constant for microsomal cytochrome P-450 is 36 times greater for the d-enantiomer. Enzymatic inhibition and affinity are highly correlated for each of the isomers as well as for the racemic mixture. Spectral analysis of the interactions of the inhibitors with the substrate supports the evidence for participation of cytochrome P-450 in aromatization.

Footnotes

* This work was supported in part by USPHS Grant AM-10081 and NICHHD Contract NIH-70-2319.

{dagger} Current address: University of Arizona Health Sciences Center, Department of Internal Medicine, Tucson, Arizona 85724.

Received November 30, 1978.




This article has been cited by other articles:


Home page
Biol. Reprod.Home page
B.-M. Huang, K.-Y. Hsiao, P.-C. Chuang, M.-H. Wu, H.-A. Pan, and S.-J. Tsai
Upregulation of Steroidogenic Enzymes and Ovarian 17{beta}-Estradiol in Human Granulosa-Lutein Cells by Cordyceps sinensis Mycelium
Biol Reprod, May 1, 2004; 70(5): 1358 - 1364.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
J. Geisler, S. Lundgren, H. Berntsen, J. L. Greaves, and P. E. Lønning
Influence of Dexaminoglutethimide, an Optical Isomer of Aminoglutethimide, on the Disposition of Estrone Sulfate in Postmenopausal Breast Cancer Patients
J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2687 - 2693.
[Abstract] [Full Text]


Home page
Hum Exp ToxicolHome page
N.P. Rowell, O.J.A. Gilmore, and P.N. Plowman
Aminoglutethimide as Second-line Hormonal Therapy in Advanced Breast Cancer: Response and Toxicity
Human and Experimental Toxicology, May 1, 1987; 6(3): 227 - 232.
[Abstract] [PDF]


Home page
ANN INTERN MEDHome page
R. J. SANTEN, T. J. WORGUL, A. LIPTON, H. HARVEY, A. BOUCHER, E. SAMOJLIK, and S. A. WELLS
Aminoglutethimide as Treatment of Postmenopausal Women with Advanced Breast Carcinoma
Ann Intern Med, January 1, 1982; 96(1): 94 - 101.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1979 by The Endocrine Society