help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rall, L. B.
Right arrow Articles by Rutter, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rall, L. B.
Right arrow Articles by Rutter, W. J.

Endocrinology, Vol 105, 835-841, Copyright © 1979 by Endocrine Society

ARTICLES

Synthesis and accumulation of proinsulin and insulin during development of the embryonic rat pancreas

LB Rall, RL Pictet and WJ Rutter

Endocrine B cells differentiate normally in embryonic rat pancreatic rudiments cultured in vitro. The specific concentration of immunoreactive insulin based on total protein increases by about 1000- fold during the developmental period, corresponding to days 13--20 of gestation. The rate of (pro)insulin synthesis, measured from the level of radioactive leucine incorporated into insulin, quantitatively accounts for the insulin accumulated during this period. In addition, the relative incorporation of leucine into proinsulin compared to insulin is constant during development and is similar to that found in the B cells of adult islets. Thus, there appears to be no significant change in the rate of conversion of proinsulin to insulin during B cell differentiation.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
A. NANDI, Y. KITAMURA, C. R. KAHN, and D. ACCILI
Mouse Models of Insulin Resistance
Physiol Rev, April 1, 2004; 84(2): 623 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Nakae, Y. Kido, and D. Accili
Distinct and Overlapping Functions of Insulin and IGF-I Receptors
Endocr. Rev., December 1, 2001; 22(6): 818 - 835.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D Gu and N Sarvetnick
Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice
Development, January 5, 1993; 118(1): 33 - 46.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1979 by The Endocrine Society