help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldfine, I. D.
Right arrow Articles by Arieff, A. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldfine, I. D.
Right arrow Articles by Arieff, A. I.

Endocrinology, Vol 105, 920-922, Copyright © 1979 by Endocrine Society

ARTICLES

Rapid inibition of basal and glucose-stimulated insulin release by xylazine

ID Goldfine and AI Arieff

Xylazine is a tranquilizer that is widely used in both biomedical research and veterinary medicine. We now report that in dogs, clinically effective doses of xylazine both markedly decrease basal insulin levels and completely abolish the rise in insulin produced by iv glucose. These changes in insulin levels lead to elevations of fasting plasma glucose and glucose intolerance. In contrast, glucagon levels are unchanged. These studies suggest that xylazine may be a useful agent in the study of glucose metabolism and beta-cell function.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
J. K. Saha, J. Xia, S. K. Engle, Y.-F. Chen, W. Glaesner, and J. A. Jakubowski
A Model of Controlled Acute Hyperglycemia in Rats: Effects of Insulin and Glucagon-Like Peptide-1 Analog
J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1159 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. Kobayashi, H. Kato, Y. Hirabayashi, H. Murakami, and H. Suzuki
Modulations of Muscle Protein Metabolism by Branched-Chain Amino Acids in Normal and Muscle-Atrophying Rats
J. Nutr., January 1, 2006; 136(1): 234S - 236S.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. K. Saha, J. Xia, J. M. Grondin, S. K. Engle, and J. A. Jakubowski
Acute Hyperglycemia Induced by Ketamine/Xylazine Anesthesia in Rats: Mechanisms and Implications for Preclinical Models
Experimental Biology and Medicine, November 1, 2005; 230(10): 777 - 784.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z.-Q. Zhao, J. C. Todd, H. Sato, X.-L. Ma, and J. Vinten-Johansen
Adenosine inhibition of neutrophil damage during reperfusion does not involve KATP-channel activation
Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1677 - H1687.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1979 by The Endocrine Society