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Endocrinology, Vol 105, 1416-1418, Copyright © 1979 by Endocrine Society

ARTICLES

Enhancement of immunoreactive somatostatin release into hypophysial portal blood by electrical stimulation of the preoptic area in the rat

K Chihara, A Arimura, C Kubli-Garfias and AV Schally

Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane- anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunoreactive somatostatin. The flow rate of portal blood also increased significantly by electrical stimuli to the preoptic area but not to the ventromedial hypothalamus. These findings support the view that the preoptic area plays an inhibitory role in the regulation of GH secretion by increasing the release of somatostatin into hypophysial portal vessels in the rat.


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P. Plotsky and W Vale
Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat
Science, October 25, 1985; 230(4724): 461 - 463.
[Abstract] [PDF]


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Copyright © 1979 by The Endocrine Society