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Endocrinology, doi:10.1210/endo-106-3-649
Endocrinology Vol. 106, No. 3 649-654
Copyright © 1980 by the Endocrine Society.
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Ventromedial Hypothalamic Lesions Abolish Food-Shifted Circadian Adrenal and Temperature Rhythinicity*

DOROTHY T. KRIEGER{dagger}

Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center New York, New York 10029

Abstract

Daytime restriction of food and water availability in nocturnal animals phase-shifts the circadian periodicity of plasma corticosteroid concentrations and body temperature. These shifted rhythms do not persist in animals with lesions of the ventromedial hypothalamus, in contrast to our previous reports of persistence of such shifted rhythms in animals with lesions of the suprachiasmatic nuclei. These findings suggest that the ventromedial hypothalamus may be the anatomical locus which mediates the circadian response to food synchronization. (Endocrinology 106: 649, 1980)

Footnotes

* This work was supported in part by NIH Grant NS023893 and the Lita Annenberg Hazen Charitable Trust Fund.

{dagger} To whom requests for reprints should be addressed.

Received July 16, 1979.




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Copyright © 1980 by The Endocrine Society