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Decreased Serum 3,5,3'-Triiodothyronine and Thyroxine Levels Accompanying Acute and Chronic Ritalin Treatment of Developing Rats^*

Biological Sciences Research Center, Departments of Pharmacology and Medicine, University of North Carolina School of Medicine Chapel Hill, North Carolina 27514

Address requests for reprints to: Dr. George Greeley, Jr., Biological Sciences Research Center, Building 220H, Room 241, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514.

Abstract

Basal serum levels of T₃, T₄, and TSH and the serum TSH increment after TRH are reported for rats chronically or acutely treated with ritalin. Serum levels of T₃ and T₄ are significantly reduced in rats chronically treated with ritalin twice daily for 21 days. Female rats appear to be more susceptible than males to the suppressive action of ritalin. Ritalin appears to accelerate the circulatory clearance of serum T₃ and T₄. Basal serum levels of TSH demonstrate graded elevations after sequentially higher doses of ritalin and, in most cases, hypophyseal responsivity (TSH) to TRH challenge appears to be margimilly enhanced by chronic ritalin treatment. Thyroidal responsiveness is not adversely affected by chronic ritalin treatment. Serum T₃ and T₄ levels return to normal levels after chronic ritalin treatment is discontinued; however, the maturational rise of the basal serum level of TSH is permanently depressed in 35 and 100 mg/ kg BW ritalin-treated males. Acute administration of ritalin (35 or 100 mg/kg BW) results in a significant reduction of the serum levels of T₃ and T₄ within 5 h and depressed levels persist for 18 days. (Endocrinology 106: 898, 1980)

Footnotes

^* Preliminary reports of this work have been made at the annual FASEB meetings of 1978 and 1979. This work was supported by NIMH Grant HD-10570 and a Research Career Development Award (to J.S.K.) from the NIMH (MH-00114-01A1).

Received March 16, 1979.

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