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Endocrinology, Vol 106, 1323-1326, Copyright © 1980 by Endocrine Society

ARTICLES

High levels of beta-endorphin in hypophyseal portal blood

SL Wardlaw, WB Wehrenberg, M Ferin, PW Carmel and AG Frantz

beta-Endorphin was measured by RIA in the hypophyseal portal blood of six pig tailed monkeys after pituitary stalk section. The mean beta- endorphin concentration was 4,770 pg/ml (range, 2,900-10,500 pg/ml). This was more than 100 times greater than the mean simultaneous peripheral venous concentration, which was less than or equal to 45 pg/ml. After gel filtration of the portal plasma extracts, the majority of beta-endorphin immunoactivity eluted as a single peak coincident with synthetic beta-endorphin standard. The demonstration of high levels of beta-endorphin in the hypophyseal portal blood suggests that endogenous opioids of hypothalamic origin are secreted into the portal blood and may directly affect the pituitary.


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S. Risch, R. Cohen, D. Janowsky, N. Kalin, and D. Murphy
Mood and behavioral effects of physostigmine on humans are accompanied by elevations in plasma beta-endorphin and cortisol
Science, September 26, 1980; 209(4464): 1545 - 1546.
[Abstract] [PDF]


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