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Endocrinology, Vol 106, 1512-1520, Copyright © 1980 by Endocrine Society

ARTICLES

Immunohistochemical localization of gamma-endorphin in the rat pituitary gland and hypothalamus

H Vaudry, G Pelletier, J Guy, R Leclerc and S Jegou

To gain more information about cells and organelles involved in the secretion of gamma-endorphin in the rat pituitary gland, an immunohistochemical localization of this peptide was conducted at both light and electron microscopic levels. Using an antiserum to gamma- endorphin which shows little cross-reactivity with beta-lipotropin (beta-LPH) and beta-endorphin, it has been demonstrated that gamm- endorphin is present in all cells of the intermediate lobe and the corticotropic cells of the anterior lobe. At the electron microscopic level, staining for gamma-endorphin was restricted to the secretory granules which also contain ACTH and beta-LPH, suggesting that all of these peptides are released concomitantly during exocytosis. In the hypothalamus, immunostaining possibly related to both gamma- and beta- endorphin but not to beta-LPH was also observed in nerve fibers and not in cell bodies.




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Copyright © 1980 by The Endocrine Society