help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Magyar, D. M.
Right arrow Articles by Nathanielsz, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Magyar, D. M.
Right arrow Articles by Nathanielsz, P. W.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*HYDROCORTISONE

Endocrinology, Vol 107, 155-159, Copyright © 1980 by Endocrine Society

ARTICLES

Time-trend analysis of plasma cortisol concentrations in the fetal sheep in relation to parturition

DM Magyar, D Fridshal, CW Elsner, T Glatz, J Eliot, AH Klein, KC Lowe, JE Buster and PW Nathanielsz

Using a cortisol RIA carefully validated for specificity in fetal ovine plasma, we studied plasma cortisol time-trend changes in eight chronically catheterized sheep fetuses in the last 22 days of gestation before the spontaneous onset of labor. Best fit exponential type curves were drawn for each individual fetus to define the time before the onset of labor at which fetal plasma cortisol was rising at different rates. Fetal plasma cortisol increased at a rate of 0.5 ng ml-1 day-1 as early as 17.1 days before labor in one fetus, whereas the mean value for all eight fetuses occurred 11.8 +/- 1.0 (SEM) days before labor. The rate of increase doubled to 1.0 ng cortisol ml-1 day-1 as early as 14.4 days before labor in one fetus, whereas the mean value for all eight fetuses occurred 9.3 +/- 0.9 days before labor. These findings suggest that the regulatory mechanisms responsible for the prelabor increase in fetal cortisol production are activated earlier in gestation than we previously thought.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. A. Ducsay, K. Hyatt, M. Mlynarczyk, B. K. Root, K. M. Kaushal, and D. A. Myers
Long-term hypoxia modulates expression of key genes regulating adrenomedullary function in the late gestation ovine fetus
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1997 - R2005.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. G. Frasch, T. Muller, C. Wicher, C. Weiss, M. Lohle, K. Schwab, H. Schubert, P. W. Nathanielsz, O. W. Witte, and M. Schwab
Fetal body weight and the development of the control of the cardiovascular system in fetal sheep
J. Physiol., March 15, 2007; 579(3): 893 - 907.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. C. Carey, S. B. Tatter, and J. C. Rose
Ontogeny and Effects of Hypothalamic Pituitary Disconnection on Formation of Inositol Trisphosphate in Fetal Sheep Pituitary Cells
Endocrinology, March 1, 2007; 148(3): 1440 - 1444.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. J. W. Fletcher, D. S. Gardner, C. M. B. Edwards, A. L. Fowden, and D. A. Giussani
Development of the ovine fetal cardiovascular defense to hypoxemia towards full term
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3023 - H3034.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. D. Giraud, S. Louey, S. Jonker, J. Schultz, and K. L. Thornburg
Cortisol Stimulates Cell Cycle Activity in the Cardiomyocyte of the Sheep Fetus
Endocrinology, August 1, 2006; 147(8): 3643 - 3649.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. C. Carey, Y. Su, N. K. Valego, and J. C. Rose
Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep
Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E214 - E220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. A. Myers, K. Hyatt, M. Mlynarczyk, I. M. Bird, and C. A. Ducsay
Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1707 - R1714.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. E. Bell, T. J. McDonald, and D. A. Myers
Proopiomelanocortin Processing in the Anterior Pituitary of the Ovine Fetus after Lesion of the Hypothalamic Paraventricular Nucleus
Endocrinology, June 1, 2005; 146(6): 2665 - 2673.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Lohle, T. Muller, C. Wicher, M. Roedel, H. Schubert, O. W Witte, P. W Nathanielsz, and M. Schwab
Betamethasone effects on fetal sheep cerebral blood flow are not dependent on maturation of cerebrovascular system and pituitary-adrenal axis
J. Physiol., April 15, 2005; 564(2): 575 - 588.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. J. W. Fletcher, A. J. Forhead, A. L. Fowden, W. R. Ford, P. W. Nathanielsz, and D. A. Giussani
Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation
J. Physiol., January 15, 2005; 562(2): 493 - 505.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. A. Kutzler, E. K Ruane, T. Coksaygan, S. E. Vincent, and P. W. Nathanielsz
Effects of Three Courses of Maternally Administered Dexamethasone at 0.7, 0.75, and 0.8 of Gestation on Prenatal and Postnatal Growth in Sheep
Pediatrics, February 1, 2004; 113(2): 313 - 319.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. Boland, B. J. Joyce, M. J. Wallace, H. Stanton, A. J. Fosang, R. A. Pierce, R. Harding, and S. B. Hooper
Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep
J. Physiol., January 15, 2004; 554(2): 505 - 517.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. M. Blanks, M. Vatish, M. J. Allen, G. Ladds, N. C. J. de Wit, D. M. Slater, and S. Thornton
Paracrine Oxytocin and Estradiol Demonstrate a Spatial Increase in Human Intrauterine Tissues with Labor
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3392 - 3400.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Owen and S. G. Matthews
Glucocorticoids and Sex-Dependent Development of Brain Glucocorticoid and Mineralocorticoid Receptors
Endocrinology, July 1, 2003; 144(7): 2775 - 2784.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Segar, T. Van Natta, and O. J. Smith
Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R460 - R467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. D. Sysyn, K. H. Petersson, C. S. Patlak, G. B. Sadowska, and B. S. Stonestreet
Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R547 - R553.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. R.G. Challis, S. G. Matthews, W. Gibb, and S. J. Lye
Endocrine and Paracrine Regulation of Birth at Term and Preterm
Endocr. Rev., October 1, 2000; 21(5): 514 - 550.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
D. A. Myers, M. E. Bell, T. J. McDonald, and T. R. Myers
Corticotropin-Releasing Factor Receptor Expression in the Pituitary of Fetal Sheep after Lesion of the Hypothalamic Paraventricular Nucleus
Endocrinology, September 1, 1999; 140(9): 4292 - 4299.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Petershack, S. C. Nagaraja, and E. N. Guillery
Role of glucocorticoids in the maturation of renal cortical Na+-K+-ATPase during fetal life in sheep
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1825 - R1832.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J.N. Ingram, G. Shaw, and M.B. Renfree
Cortisol in Fetal Fluids and the Fetal Adrenal at Parturition in the Tammar Wallaby (Macropus eugenii)
Biol Reprod, March 1, 1999; 60(3): 651 - 655.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Unno, C. H. Wong, S. L. Jenkins, R. A. Wentworth, X.-Y. Ding, C. Li, S. S. Robertson, W. P. Smotherman, and P. W. Nathanielsz
Blood pressure and heart rate in the ovine fetus: ontogenic changes and effects of fetal adrenalectomy
Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H248 - H256.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. E. Bell, T. R. Myers, and D. A. Myers
Expression of Proopiomelanocortin and Prohormone Convertase-1 and -2 in the Late Gestation Fetal Sheep Pituitary
Endocrinology, December 1, 1998; 139(12): 5135 - 5143.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. E. Boland, L. Nardo, and S. B. Hooper
Cortisol pretreatment enhances the lung growth response to tracheal obstruction in fetal sheep
Am J Physiol Lung Cell Mol Physiol, December 1, 1997; 273(6): L1126 - L1131.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. E. Bell, T. R. Myers, T. J. McDonald, and D. A. Myers
Fetal Sheep Pituitary Proopiomelanocortin in Late Gestation: Effect of Bilateral Lesions of the Paraventricular Nucleus on Regional and Cellular Messenger Ribonucleic Acid Levels
Endocrinology, September 1, 1997; 138(9): 3873 - 3880.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. C. Taylor, D. Wu, Y. Soong, J. S. Yee, and H. H. Szeto
Opioid Modulation of the Fetal Hypothalamic-Pituitary-Adrenal Axis: The Role of Receptor Subtypes and Route of Administration
J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 129 - 135.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
N. Unno, D. A. Giussani, W. K. H. M. A Hing, X. Y. Ding, J. H. Collins, and P. W. Nathanielsz
Changes in Adrenocorticotropin and Cortisol Responsiveness after Repeated Partial Umbilical Cord Occlusions in the Late Gestation Ovine Fetus
Endocrinology, January 1, 1997; 138(1): 259 - 263.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
J. B. Derks, D. A. Giussani, L. M. Van Dam, S. L. Jenkins, J. A. Winter, X. F. Zhao, G. L. Hammond, and P. W. Nathanielsz
Differential Effects of Betamethasone and Dexamethasone Fetal Administration of Parturition in Sheep
Reproductive Sciences, November 1, 1996; 3(6): 336 - 341.
[Abstract] [PDF]

Home page
 Reproductive SciencesHome page
Wen Wu and P. W. Nathanlelsz
Changes in Oxytocin Receptor Messenger RNA in the Endometrium, Myometrium, Mesometrium, and Cervix of Sheep in Late Gestation and During Spontaneous and Cortisol-Induced Labor
Reproductive Sciences, July 1, 1994; 1(3): 191 - 196.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1980 by The Endocrine Society