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Endocrinology, Vol 107, 755-760, Copyright © 1980 by Endocrine Society

ARTICLES

Levels of neurohypophyseal peptides in the rat during the first month of life. II. Response to physiological stimuli

C Singinq, AG Robinson and SM Seif

Levels of vasopressin, oxytocin, and neurophysin were measured by RIA in the hypothalamus, pituitary, and plasma of infant rats (2-30 days old). At all ages, ip injection of a hypertonic solution of 5 g/100 ml NaCl produced a marked increase in levels of vasopressin and neurophpysin in plasma, up to 21 microU/ml and 51 ng/ml, respectively. After dehydration, there was a decrease of 26-38% in the levels of neurohypophyseal peptides in the pituitary. Depletion of neurohypophyseal peptides from the pituitary was greater after 24 h of dehydration in younger rats (26%) than in older rats (7%). Levels of vasopressin in plasma were less than 1.7 microU/ml after dehydration in younger rats but were greater in older rats. Immaturity of the neurohypophysis may contribute to the inability of newborn rats to withstand prolonged dehydration.




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