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Endocrinology, Vol 107, 1320-1326, Copyright © 1980 by Endocrine Society

ARTICLES

Calcium regulatory action of endogenous rat calcitonin demonstrated by passive immunization with calcitonin antibodies

BA Roos, M Yoon, SV Cutshaw and DN Kalu

The calcium regulatory role of calcitonin (CT) in murine physiology was evaluated with a combination of immunological techniques, bioassays, and gland ablation. Passive immunization of rats with neutralizing CT antibodies caused an immediate but transient increase in plasma calcium with a time course similar to that observed in thyroparathyroidectomized animals. In animals fasted during the day and fed at night (1700-0700 h), acutely decreasing endogenous CT (< 100 pg/ml) by thyroparathyroidectomy or by passive immunization with CT antibodies resulted in a greater increase in plasma calcium in the preprandial (1600 h) than in the postprandial inverse correlation between immunoreactive CT and plasma calcium, a known secretagogue for CT. In these animals on a restricted feeding schedule, a sharp preprandial (1600 h) rise in immunoreactive and bioactive CT and a circadian rhythm in plasma calcium were also observed. The onset of the increase in circulating CT preceded the onset of feeding and coincided with or shortly preceded the daily nadir of plasma calcium. These findngs establish that CT has a primary calcium regulatory role in murine physiology. More specifically, they demonstrate that 1) the postthyroparathyroidectomy increase in plasma calcium is due specifically to the loss of CT, 2) passive immunization is a feasible technique for evaluating the actions of endogenous CT, 3) the role of CT in calcium regulation cannot be restricted to that of preventing prandial and postprandial increase in blood calcium, and 4) factors other than calcium must be involved in the control of CT secretion in the nonfed state.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. A. Schmid, M. Rauch, and J. Koch
Effect of calcitonin on the activity of ANG II-responsive neurons in the rat subfornical organ
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1646 - R1652.
[Abstract] [Full Text] [PDF]


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