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Induction of Nuclear Androgen-Binding Sites in Epithelium of the Embryonic Urinary Bladder by Mesenchyme of the Urogenital Sinus of Embryonic Mice^*

Department of Anatomy, University of Colorado, Denver, Colorado 80262

Address requests for reprints to: Dr. Gerald R. Cunha, Department of Anatomy, University of Colorado, 4200 East Ninth Avenue, Denver, Colorado 80262.

Abstract

Mesenchyme of the embryonic urogenital sinus induces epithelium of the embryonic urinary bladder to form prostatic acini. The induced glandular epithelium exhibits nuclear androgen-binding sites, as demonstrated autoradiographically. This suggests that the expression of androgen receptor activity in an epithelium is dependent upon the mesenchyme with which it is associated during development.

Footnotes

^* This work was supported in part by NCI Contract Grant NO 1- CP-75875 and Grant PDT-139 from the American Cancer Society.

Received March 17, 1980.

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