help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Terry, L. C.
Right arrow Articles by Crowley, W. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Terry, L. C.
Right arrow Articles by Crowley, W. R.

Endocrinology, Vol 107, 1771-1775, Copyright © 1980 by Endocrine Society

ARTICLES

The effect of hypophysectomy on somatostatin-like immunoreactivity in discrete hypothalamic and extrahypothalamic nuclei

LC Terry and WR Crowley

Several hypothalamic and extrahypothalamic sites that have high concentrations of somatostatin-positive nerve terminals and/or cell bodies are important in the regulation of GH secretion. GH is capable of inhibiting its own secretion under certain prescribed conditions, and a short loop feedback regulatory mechanism may involve somatostatinergic pathways. The purpose of this investigation was to determine the effect of removal of GH by hypophysectomy on the content of somatostatin-like immunoreactivity (SLI) in discrete hypothalamic and extrahypothalamic nuclei. Individual nuclei were removed from frozen brain sections of hypophysectomized and sham-operated male rats. The tissue content of somatostatin was determined by a specific RIA. The content of SLI in the median eminence of hypophysectomized animals was significantly reduced by 38%, compared to sham-operated controls (278 +/- 53.2 vs. 447.0 +/- 57.4 pg/microgram protein, respectively). Significant reductions of SLI in the medial preoptic (50%), arcuate (33%), and periventricular (30%) nuclei were also observed in hypophysectomized animals when compared to controls (10.2 +/- 1.6 vs. 20.0 +/- 3.0; 60.2 +/- 8.2 vs. 89.8 +/- 13.3; and 19.4 +/- 1.8 vs. 27.8 +/- 3.1 pg/microgram protein, respectively). No significant changes were detected in the ventromedial, suprachiasmatic, medial, central, or cortical a mygdaloid nuclei nor in the nucleus interstitialis striae terminalis. These data suggest that GH may exert a feedback effect on specific hypothalamic nuclei that involves somatostatin-containing systems.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
G.-F. Chen, M. J. J. Ronis, P. E. Thomas, D. J. Flint, and T. M. Badger
Hormonal Regulation of Microsomal Cytochrome P450 2C11 in Rat Liver and Kidney
J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1486 - 1494.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1980 by The Endocrine Society