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Endocrinology, Vol 107, 2115-2116, Copyright © 1980 by Endocrine Society


ARTICLES

Postovulatory decrease in estrogen production is caused by the diminished supply of aromatizable androgen to ovarian aromatase

K Suzuki and BI Tamaoki

After administration of testosterone to immature rats which had ovulated after treatment with PMSG and hCG, a significant increase in ovarian content of estradiol-17 beta was observed. Together with our previous result on the immediate decrease in ovarian 17 alpha- hydroxylase and C-17-C-20 lyase after PMSG and hCG treatment, it is concluded that the drastic decrease in serum estradiol-17 beta after ovulation is caused by a shortage of supply of aromatizable androgen(s) to the ovarian aromatase, due to diminished activities of the above two enzymes.





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Copyright © 1980 by The Endocrine Society