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Endocrinology, Vol 107, 2121-2123, Copyright © 1980 by Endocrine Society

ARTICLES

Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells

RS Bahn, KV Speeg Jr, M Ascoli and D Rabin

Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.


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