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Endocrinology, Vol 107, 2133-2134, Copyright © 1980 by Endocrine Society

ARTICLES

Gonadotropin release from pituitary cultures following activation of endogenous ion channels

PM Conn and DC Rogers

In primary rat pituitary cell cultures, activation of Na+ channels resulted in Na+ and Ca2+ dependent gonadotropin release. This occurred with the same efficacy and over the same time course as that stimulated by gonadotropin releasing hormone (GnRH). In contrast, GnRH required extracellular Ca2+, but not Na+ for its action. These results indicate that the gonadotrope has ion channels which resemble those found in neural tissues.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1980 by The Endocrine Society