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Endocrinology, Vol 108, 179-182, Copyright © 1981 by Endocrine Society

ARTICLES

Influence of thyrotropin-releasing hormone on the secretion of thyrotropin in neonatal rats

C Oliver, P Giraud, JC Lissitzky, B Contye-Devolx and P Gillioz

Two hours after the ip administration of TRH antiserum, no change in serum TSH concentration was observed in the rat from birth through day 5 of life. Under the same conditions, a significant reduction in serum TSH was observed in 7- to 14-day-old rats. Similarly, in neonatal hypothyroidism, TSH levels did not change in 1-day-old rats, whereas a significant decrease was observed on day 7. The administration of synthetic TRH during the neonatal period induced a significant increase of serum TSH in the newborn; however, TSH release by the pituitary gland increased progressively from days 3-10. Immunoreactive TRH was undetectable in the serum of newborn rats. Adult levels were reached when the rats were 10 days old. It is concluded that neonatal pituitary- thyroid function in the rat is not physiologically dependent upon TRH secretion, although synthetic TRH is able to stimulate the secretion of TSH at birth.




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Copyright © 1981 by The Endocrine Society