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Endocrinology, Vol 108, 420-426, Copyright © 1981 by Endocrine Society

ARTICLES

Stimulation of a D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland decreases the responsiveness of the beta- adrenoceptor: biochemical mechanism

TE Cote, CW Grewe and JW Kebabian

In experiments using a cell-free homogenate of the intermediate lobe of the hypophysis of the rat, apomorphine, a dopaminergic agonist, diminished both basal and L-isoproterenol-stimulated adenylate cyclase activity; dopaminergic antagonists from several chemical families reversed these inhibitory effects of apomorphine. Apomorphine diminished the ability of GTP to enhance both basal and L-isoproterenol- stimulated adenylate cyclase activity but did not directly interfere with the interaction between the beta-adrenoceptor and L-isoproterenol. The affinity of the D-2 dopamine receptor in the intermediate lobe for each dopaminergic antagonist used in this study was estimated from a mathematical analysis of the data. (Endocrinology 108: 420, 1981)


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S. Snyder
Drug and neurotransmitter receptors in the brain
Science, April 6, 1984; 224(4644): 22 - 31.
[Abstract] [PDF]


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Copyright © 1981 by The Endocrine Society