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Endocrinology, Vol 108, 723-725, Copyright © 1981 by Endocrine Society

ARTICLES

Transition from neurogenic to myogenic receptivity for thyrotropin- releasing hormone (TRH) in the duodenum of the neonatal rat

T Tonoue, K Furukawa and T Nomoto

A tetrodotoxin- and hexamethonium-sensitive response to thyrotropin- releasing hormone (TRH), an in vitro contraction, first appeared in the duodenum of the 3 day old rat, was increased by day 16, decreased there- after and was extinguished after weaning. A tetrodotoxin-resistant response to TRH, a relaxation, appeared at day 13 and became distinct after weaning. The development of neurogenic receptivity for TRH precedes the appearance of myogenic receptivity in the rat duodenum.


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E. A. Nillni and K. A. Sevarino
The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides
Endocr. Rev., October 1, 1999; 20(5): 599 - 648.
[Abstract] [Full Text]


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