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Endocrinology, Vol 108, 730-732, Copyright © 1981 by Endocrine Society

ARTICLES

Effect of exogenous zinc on insulin secretion in vitro

DP Figlewicz, A Heldt, SE Forhan and GM Grodsky

The effect of varying exogenous zinc concentrations on insulin secretion by the perfused pancreas and short-term cultured islets was studied. No significant effect was observed at several supraphysiologic concentrations unless islets were cultured with 200 microM added zinc. These results suggest that exposure of the pancreas to non-physiologic zinc levels is necessary in order to influence the insulin secretory process.




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Copyright © 1981 by The Endocrine Society