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Endocrinology, Vol 108, 1403-1406, Copyright © 1981 by Endocrine Society

ARTICLES

Thyrotropin secretory response to thyrotropin-releasing hormone in the hypothyroid perinatal rat: further evidence of thyrotroph independence of the hypothalamus during early ontogenesis

V Strbak and MA Greer

Propylthiouracil fed to pregnant rats for the last week of gestation to induce maternal and fetal hypothyroidism induced a 3-fold rise in plasma TSH concentration in the newborn pups compared to a 4-fold rise in their mothers. Subcutaneous administration of 1 ng/g BW TRH caused a greater rise in plasma TSH in the hypothyroid pups than in their mothers. These results, in combination with published data, indicate that the apparent independence of pituitary-thyroid function from TRH control during early ontogenesis in the rat is primarily due to delayed maturation of the hypothalamic TRH system.


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K. Valentijn, F. Vandenbulcke, E. Piek, J.-C. Beauvillain, and H. Vaudry
Distribution, Cellular Localization, and Ontogeny of Preprothyrotropin-Releasing Hormone-(160-169) (Ps4)-Binding Sites in the Rat Pituitary
Endocrinology, March 1, 1998; 139(3): 1306 - 1313.
[Abstract] [Full Text] [PDF]


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