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Endocrinology, Vol 108, 1995-1997, Copyright © 1981 by Endocrine Society


ARTICLES

Specific radioimmunoassay of cyclo (His-Pro), a biologically active metabolite of thyrotropin-releasing hormone

M Mori, C Prasad and JF Wilber

We have developed a radioimmunoassay that can detect 10 pg cyclo (His- Pro) in rat brain perchloric acid extracts. The normal rat brain concentration of cyclo (His-Pro) ranged from 35-61 pmole/brain. The elution profiles of cyclo (His-Pro)-like immunoreactivity and radioactive cyclo (His-Pro) following gel filtration and ion-exchange chromatography were similar.


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L.J. Jara, C. Prasad, and L.R. Espinoza
Elevated serum levels of cyclo (His-Pro), an endogenous inhibitor of pituitary prolactin secretion, in systemic lupus erythematosus patients
Lupus, January 1, 1997; 6(3): 258 - 260.
[Abstract] [PDF]




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