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Endocrinology, Vol 108, 2005-2007, Copyright © 1981 by Endocrine Society

ARTICLES

Nicotinamide adenine dinucleotide and renal response to parathyroid hormone

TJ Berndt, FG Knox, SA Kempson and TP Dousa

We tested the hypothesis that NAD plays a role in the cellular mechanism of action of parathyroid hormone (PTH) on phosphate transport. PTH significantly increased urinary cyclic AMP and phosphate excretions in thyroparathyroidectomized rats. The NAD+/NADH ratio, but not total NAD content, in renal cortical tissue was significantly higher in rats infused with PTH than in controls. The results demonstrate that the phosphaturic effect of PTH is associated with a shift in the renal cortical NADH to NAD+ and provides evidence for a role for NAD+ in the cellular regulation of phosphate transport.




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Copyright © 1981 by The Endocrine Society