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Endocrinology, Vol 108, 2008-2010, Copyright © 1981 by Endocrine Society


ARTICLES

Isolation and characterization of rat hypothalamic somatostatin-14

P Bohlen, R Benoit, N Ling, R Guillemin and P Brazeau

A peptide with somatostatin-like immuno- and bioactivity has been isolated from 1165 rat hypothalami by using antisomatostatin affinity chromatography, gel filtration and reverse-phase high-performance liquid chromatography. The isolated peptide is indistinguishable from synthetic somatostatin-14 with respect to chromatographic properties and amino acid composition. We therefore propose that rat hypothalamic somatostatin-14 is identical in structure to somatostatin-14 found in other species.





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Copyright © 1981 by The Endocrine Society