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Endocrinology, Vol 108, 2385-2387, Copyright © 1981 by Endocrine Society

ARTICLES

Blood-borne adrenocorticotropin binds specifically to the median eminence-arcuate region of the rat hypothalamus

M van Houten, MN Khan, RJ Khan and BI Posner

The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventral arcuate nucleus. This localization may indicate that the hypophysiotropic median eminence is a new target site for circulating adrenocorticotropin. Alternatively, ACTH binding sites in the median eminence-arcuate region may provide the hypothalamus with a hormone-selective capacity to concentrate pituitary ACTH for possible retrograde transport and redistribution within the central nervous system.


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 J. Neurosci.Home page
T. M. Reyes and P. E. Sawchenko
Involvement of the Arcuate Nucleus of the Hypothalamus in Interleukin-1-Induced Anorexia
J. Neurosci., June 15, 2002; 22(12): 5091 - 5099.
[Abstract] [Full Text] [PDF]


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