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Endocrinology, Vol 108, 2391-2396, Copyright © 1981 by Endocrine Society

ARTICLES

Somatostatin-28: selective action on the pancreatic beta-cell and brain

M Brown, J Rivier and W Vale

Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS- 14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine. D-Trp substitution in position 28 of SS-28 increase potency to 2600 times that of SS-14 for inhibition of arginine induced insulin secretion. SS-28 in 10 and [D-Trp22]-SS-28 is 100 times as potent as SS-14 to act within the central nervous system to inhibit bombesin induced hyperglycemia. SS-28 compared to SS-14 shows pancreatic beta-cell and brain selectivity of action.


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V. Tran, M. Beal, and J. Martin
Two types of somatostatin receptors differentiated by cyclic somatostatin analogs
Science, April 26, 1985; 228(4698): 492 - 495.
[Abstract] [PDF]


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Copyright © 1981 by The Endocrine Society