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Endocrinology, Vol 109, 17-22, Copyright © 1981 by Endocrine Society

ARTICLES

Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells

PM Yen and AH Tashjian Jr

Treatment of GH3 cells for 24-72 h with sodium valerate (1 mM) increased 2- to 4-fold the production of both PRL and GH. There was a concomitant change in the morphology of the cells that resembled that produced by TRH and epidermal growth factor. The increases in hormone production and changes in morphology were reversible. The sodium salts of butyric, hexanoic, caprylic, nonanoic, and dodecanoic acids also increased hormone production and altered cell morphology, whereas the salts of formic, acetic, and isobutyric acids did not. Acute (1-h) treatment with the fatty acids, unlike the effects of TRH and epidermal growth factor, did not increase the release of PRL from the cells.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society